3S29

The crystal structure of sucrose synthase-1 from Arabidopsis thaliana and its functional implications.

3S29 の概要

• エントリーDOI: 10.2210/pdb3s29/pdb
• 関連するPDBエントリー: 3S27 3S28
• 分子名称: Sucrose synthase 1, URIDINE-5'-DIPHOSPHATE, beta-D-fructofuranose, ... (7 entities in total)
• 機能のキーワード: glycosyltransferase, sucrose metabolism, sugar acceptor complex, rossmann fold, gt-b fold, udp, fructose, cytosol, transferase
• 由来する生物種: Arabidopsis thaliana (mouse-ear cress,thale-cress)
• タンパク質・核酸の鎖数: 8
• 化学式量合計: 762546.88

構造登録者

Zheng, Y.I.,Garavito, R.M. (登録日: 2011-05-16, 公開日: 2011-08-24, 最終更新日: 2023-09-13)

主引用文献

Zheng, Y.,Anderson, S.,Zhang, Y.,Garavito, R.M.
The Structure of Sucrose Synthase-1 from Arabidopsis thaliana and Its Functional Implications.
J.Biol.Chem., 286:36108-36118, 2011

PubMed Abstract: Sucrose transport is the central system for the allocation of carbon resources in vascular plants. During growth and development, plants control carbon distribution by coordinating sites of sucrose synthesis and cleavage in different plant organs and different cellular locations. Sucrose synthase, which reversibly catalyzes sucrose synthesis and cleavage, provides a direct and reversible means to regulate sucrose flux. Depending on the metabolic environment, sucrose synthase alters its cellular location to participate in cellulose, callose, and starch biosynthesis through its interactions with membranes, organelles, and cytoskeletal actin. The x-ray crystal structure of sucrose synthase isoform 1 from Arabidopsis thaliana (AtSus1) has been determined as a complex with UDP-glucose and as a complex with UDP and fructose, at 2.8- and 2.85-Å resolutions, respectively. The AtSus1 structure provides insights into sucrose catalysis and cleavage, as well as the regulation of sucrose synthase and its interactions with cellular targets.

PubMed: 21865170
DOI: 10.1074/jbc.M111.275974

実験手法

X-RAY DIFFRACTION (2.85 Å)