3RUT

FXR with SRC1 and GSK359

3RUT の概要

• エントリーDOI: 10.2210/pdb3rut/pdb
• 関連するPDBエントリー: 3RUU 3RVF
• 分子名称: Bile acid receptor, Nuclear receptor coactivator 1, SULFATE ION, ... (5 entities in total)
• 機能のキーワード: nuclear receptor, alpha-helical sandwich, transcription factor, rxr, transcription co-factors, bile acid, farnesoid, transcription regulator
• 由来する生物種: Homo sapiens (human); 詳細
• 細胞内の位置: Nucleus . Isoform 1: Nucleus . Isoform 2: Nucleus . Isoform 3: Nucleus . Isoform 4: Nucleus : Q96RI1; Nucleus : Q15788
• タンパク質・核酸の鎖数: 2
• 化学式量合計: 28950.00

構造登録者

Williams, S.P.,Madauss, K.P. (登録日: 2011-05-05, 公開日: 2011-09-21, 最終更新日: 2024-02-28)

主引用文献

Akwabi-Ameyaw, A.,Caravella, J.A.,Chen, L.,Creech, K.L.,Deaton, D.N.,Madauss, K.P.,Marr, H.B.,Miller, A.B.,Navas, F.,Parks, D.J.,Spearing, P.K.,Todd, D.,Williams, S.P.,Wisely, G.B.
Conformationally constrained farnesoid X receptor (FXR) agonists: Alternative replacements of the stilbene.
Bioorg.Med.Chem.Lett., 21:6154-6160, 2011

PubMed Abstract: To further explore the optimum placement of the acid moiety in conformationally constrained analogs of GW 4064 1a, a series of stilbene replacements were prepared. The benzothiophene 1f and the indole 1g display the optimal orientation of the carboxylate for enhanced FXR agonist potency.

PubMed: 21890356
DOI: 10.1016/j.bmcl.2011.08.034

実験手法

X-RAY DIFFRACTION (3 Å)