3RTP
Design and synthesis of brain penetrant selective JNK inhibitors with improved pharmacokinetic properties for the prevention of neurodegeneration
3RTP の概要
エントリーDOI | 10.2210/pdb3rtp/pdb |
分子名称 | Mitogen-activated protein kinase 10, N-[4-cyano-3-(1H-1,2,4-triazol-5-yl)thiophen-2-yl]-2-(2-oxo-3,4-dihydroquinolin-1(2H)-yl)acetamide (3 entities in total) |
機能のキーワード | jnk inhibitors, pharmacokinetic properties, neurodegeneration, transferase-transferase inhibitor complex, transferase/transferase inhibitor |
由来する生物種 | Homo sapiens (human) |
細胞内の位置 | Cytoplasm: P53779 |
タンパク質・核酸の鎖数 | 1 |
化学式量合計 | 42248.85 |
構造登録者 | Bowers, S.,Truong, A.P.,Neitz, R.J.,Hom, R.K.,Sealy, J.M.,Probst, G.D.,Quincy, Q.,Peterson, B.,Chan, W.,Galemmo Jr., R.A.,Konradi, A.W.,Sham, H.L.,Pan, H.,Lin, M.,Yao, N.,Artis, D.R.,Zhang, H.,Chen, L.,Dryer, M.,Samant, B.,Zmolek, W.,Wong, K.,Lorentzen, C.,Goldbach, E.,Tonn, G.,Quinn, K.P.,Sauer, J.,Wright, S.,Powell, K.,Ruslim, L.,Ren, Z.,Bard, F.,Yednock, T.A.,Griswold-Prenne, I. (登録日: 2011-05-03, 公開日: 2013-05-08, 最終更新日: 2024-02-28) |
主引用文献 | Bowers, S.,Truong, A.P.,Jeffrey Neitz, R.,Hom, R.K.,Sealy, J.M.,Probst, G.D.,Quincy, D.,Peterson, B.,Chan, W.,Galemmo, R.A.,Konradi, A.W.,Sham, H.L.,Toth, G.,Pan, H.,Lin, M.,Yao, N.,Artis, D.R.,Zhang, H.,Chen, L.,Dryer, M.,Samant, B.,Zmolek, W.,Wong, K.,Lorentzen, C.,Goldbach, E.,Tonn, G.,Quinn, K.P.,Sauer, J.M.,Wright, S.,Powell, K.,Ruslim, L.,Ren, Z.,Bard, F.,Yednock, T.A.,Griswold-Prenner, I. Design and synthesis of brain penetrant selective JNK inhibitors with improved pharmacokinetic properties for the prevention of neurodegeneration. Bioorg.Med.Chem.Lett., 21:5521-5527, 2011 Cited by PubMed: 21813278DOI: 10.1016/j.bmcl.2011.06.100 主引用文献が同じPDBエントリー |
実験手法 | X-RAY DIFFRACTION (2.4 Å) |
構造検証レポート
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