3RL2

HIV Nef derived peptide Nef73 complexed to HLA-A*0301

Summary for 3RL2

• Entry DOI: 10.2210/pdb3rl2/pdb
• Related: 3RL1
• Descriptor: HLA class I histocompatibility antigen, A-3 alpha chain, Beta-2-microglobulin, Nef73 peptide from Protein Nef, ... (4 entities in total)
• Functional Keywords: hla-a*0301, cd8+ t cell immunity, hiv derived peptides, immune system
• Biological source: Homo sapiens (human); More
• Cellular location: Membrane; Single-pass type I membrane protein: P04439; Secreted: P61769
• Total number of polymer chains: 3
• Total formula weight: 44611.51

Authors

Zhang, S.,Liu, J.,Cheng, H.,Tan, S.,Qi, J.,Yan, J.,Gao, G.F. (deposition date: 2011-04-19, release date: 2012-02-29, Last modification date: 2024-10-30)

Primary citation

Zhang, S.,Liu, J.,Cheng, H.,Tan, S.,Qi, J.,Yan, J.,Gao, G.F.
Structural basis of cross-allele presentation by HLA-A*0301 and HLA-A*1101 revealed by two HIV-derived peptide complexes
Mol.Immunol., 49:395-401, 2011

PubMed Abstract: Human leukocyte antigens (HLA) are initially classified by serotyping but recently can be re-grouped by their peptide-presentation characteristics into supertypes. Both HLA-A*0301 and HLA-A*1101 are grouped into A3 supertype. Although a number of cross-presented T cell epitopes of HLA-A*0301 and HLA-A*1101 have been identified, the molecular mechanisms of cross-presentation remain elusive. Herein, the structures of HLA-A*0301 with two HIV-derived immunodominant T cell epitopes were solved and their characteristics in comparison with HLA-A*1101 presenting the same peptides were analyzed. The comparable structures of HLA-A*0301 and HLA-A*1101 with subtle differences illustrate the common modes of cross-presented peptides and the strict HLA-restriction of T cell receptor (TCR)-recognition.

PubMed: 21943705
DOI: 10.1016/j.molimm.2011.08.015

Experimental method

X-RAY DIFFRACTION (2.386 Å)