3RJ7
Human carbonic anhydrase II complexed with its inhibitor rhenium(I)triscarbonyl-cyclopentadienyl-carboxy-4-aminomethylbenzene-sulfonamide
Summary for 3RJ7
Entry DOI | 10.2210/pdb3rj7/pdb |
Descriptor | Carbonic anhydrase 2, ZINC ION, MERCURIBENZOIC ACID, ... (6 entities in total) |
Functional Keywords | inhibitor, transition metal complex, anhydrase, carbon dioxide, lyase-lyase inhibitor complex, lyase/lyase inhibitor |
Biological source | Homo sapiens (human) |
Cellular location | Cytoplasm : P00918 |
Total number of polymer chains | 1 |
Total formula weight | 30631.14 |
Authors | Spingler, B.,Can, D.,Alberto, R. (deposition date: 2011-04-15, release date: 2012-02-29, Last modification date: 2023-09-13) |
Primary citation | Can, D.,Spingler, B.,Schmutz, P.,Mendes, F.,Raposinho, P.,Fernandes, C.,Carta, F.,Innocenti, A.,Santos, I.,Supuran, C.T.,Alberto, R. [(Cp-R)M(CO)(3) ] (M=Re or (99m) Tc) Arylsulfonamide, Arylsulfamide, and Arylsulfamate Conjugates for Selective Targeting of Human Carbonic Anhydrase IX. Angew.Chem.Int.Ed.Engl., 51:3354-3357, 2012 Cited by PubMed: 22344779DOI: 10.1002/anie.201107333 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (1.2 Å) |
Structure validation
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