3RJ7

Human carbonic anhydrase II complexed with its inhibitor rhenium(I)triscarbonyl-cyclopentadienyl-carboxy-4-aminomethylbenzene-sulfonamide

3RJ7 の概要

• エントリーDOI: 10.2210/pdb3rj7/pdb
• 分子名称: Carbonic anhydrase 2, ZINC ION, MERCURIBENZOIC ACID, ... (6 entities in total)
• 機能のキーワード: inhibitor, transition metal complex, anhydrase, carbon dioxide, lyase-lyase inhibitor complex, lyase/lyase inhibitor
• 由来する生物種: Homo sapiens (human)
• 細胞内の位置: Cytoplasm : P00918
• タンパク質・核酸の鎖数: 1
• 化学式量合計: 30631.14

構造登録者

Spingler, B.,Can, D.,Alberto, R. (登録日: 2011-04-15, 公開日: 2012-02-29, 最終更新日: 2023-09-13)

主引用文献

Can, D.,Spingler, B.,Schmutz, P.,Mendes, F.,Raposinho, P.,Fernandes, C.,Carta, F.,Innocenti, A.,Santos, I.,Supuran, C.T.,Alberto, R.
[(Cp-R)M(CO)(3) ] (M=Re or (99m) Tc) Arylsulfonamide, Arylsulfamide, and Arylsulfamate Conjugates for Selective Targeting of Human Carbonic Anhydrase IX.
Angew.Chem.Int.Ed.Engl., 51:3354-3357, 2012

PubMed Abstract: Enhanced receptor selectivity: carbonic anhydrase inhibitors are relevant for both cancer diagnosis and therapy. Combining non-radioactive Re compounds with their radioactive (99m)Tc homologs enables the use of identical molecules for therapy and imaging (theragnostic). The syntheses and in vitro evaluation of [(Cp-R)M(CO)(3)] (Cp=cyclopentadienyl, M=Re, (99m)Tc) with R being a highly potent carbonic-anhydrase-targeting vector is reported.

PubMed: 22344779
DOI: 10.1002/anie.201107333

実験手法

X-RAY DIFFRACTION (1.2 Å)