3RJ7

Human carbonic anhydrase II complexed with its inhibitor rhenium(I)triscarbonyl-cyclopentadienyl-carboxy-4-aminomethylbenzene-sulfonamide

3RJ7 の概要

• エントリーDOI: 10.2210/pdb3rj7/pdb
• 分子名称: Carbonic anhydrase 2, ZINC ION, MERCURIBENZOIC ACID, ... (6 entities in total)
• 機能のキーワード: inhibitor, transition metal complex, anhydrase, carbon dioxide, lyase-lyase inhibitor complex, lyase/lyase inhibitor
• 由来する生物種: Homo sapiens (human)
• 細胞内の位置: Cytoplasm : P00918
• タンパク質・核酸の鎖数: 1
• 化学式量合計: 30631.14

構造登録者

Spingler, B.,Can, D.,Alberto, R. (登録日: 2011-04-15, 公開日: 2012-02-29, 最終更新日: 2023-09-13)

• 主引用文献: Can, D.,Spingler, B.,Schmutz, P.,Mendes, F.,Raposinho, P.,Fernandes, C.,Carta, F.,Innocenti, A.,Santos, I.,Supuran, C.T.,Alberto, R.; [(Cp-R)M(CO)(3) ] (M=Re or (99m) Tc) Arylsulfonamide, Arylsulfamide, and Arylsulfamate Conjugates for Selective Targeting of Human Carbonic Anhydrase IX.; Angew.Chem.Int.Ed.Engl., 51:3354-3357, 2012; PubMed: 22344779; DOI: 10.1002/anie.201107333

実験手法

X-RAY DIFFRACTION (1.2 Å)