3RIG

Sirt5 is an NAD-dependent protein lysine demalonylase and desuccinylase

Summary for 3RIG

• Entry DOI: 10.2210/pdb3rig/pdb
• Related: 3RIY
• Descriptor: NAD-dependent deacetylase sirtuin-5, peptide of histone 3 thioacetyl-lysine 9, ZINC ION, ... (5 entities in total)
• Functional Keywords: protein lysine demalonylase/desuccinylase, zn-binding domain, rossmann fold, mitochondria, hydrolase
• Biological source: Homo sapiens (human); More
• Cellular location: Mitochondrion matrix. Isoform 1: Cytoplasm . Isoform 2: Mitochondrion : Q9NXA8
• Total number of polymer chains: 4
• Total formula weight: 62482.02

Authors

Zhou, Y. (deposition date: 2011-04-13, release date: 2011-11-23, Last modification date: 2023-11-01)

• Primary citation: Du, J.,Zhou, Y.,Su, X.,Yu, J.J.,Khan, S.,Jiang, H.,Kim, J.,Woo, J.,Kim, J.H.,Choi, B.H.,He, B.,Chen, W.,Zhang, S.,Cerione, R.A.,Auwerx, J.,Hao, Q.,Lin, H.; Sirt5 is a NAD-dependent protein lysine demalonylase and desuccinylase; Science, 334:806-809, 2011; PubMed: 22076378; DOI: 10.1126/science.1207861

Experimental method

X-RAY DIFFRACTION (2 Å)