3RIG

Sirt5 is an NAD-dependent protein lysine demalonylase and desuccinylase

Summary for 3RIG

Related3RIY
DescriptorNAD-dependent deacetylase sirtuin-5, peptide of histone 3 thioacetyl-lysine 9, ZINC ION, ... (5 entities in total)
Functional Keywordsprotein lysine demalonylase/desuccinylase, zn-binding domain, rossmann fold, mitochondria, hydrolase
Biological sourceHomo sapiens (human)
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Cellular locationMitochondrion matrix. Isoform 1: Cytoplasm . Isoform 2: Mitochondrion  Q9NXA8
Total number of polymer chains4
Total molecular weight62482.02
Authors
Zhou, Y. (deposition date: 2011-04-13, release date: 2011-11-23, Last modification date: 2017-11-08)
Primary citation
Du, J.,Zhou, Y.,Su, X.,Yu, J.J.,Khan, S.,Jiang, H.,Kim, J.,Woo, J.,Kim, J.H.,Choi, B.H.,He, B.,Chen, W.,Zhang, S.,Cerione, R.A.,Auwerx, J.,Hao, Q.,Lin, H.
Sirt5 is a NAD-dependent protein lysine demalonylase and desuccinylase
Science, 334:806-809, 2011
PubMed: 22076378 (PDB entries with the same primary citation)
DOI: 10.1126/science.1207861
MImport into Mendeley
Experimental method
X-RAY DIFFRACTION (2 Å)
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Structure validation

RfreeClashscoreRamachandran outliersSidechain outliersRSRZ outliers0.27091.4%4.0%7.0%MetricValuePercentile RanksWorseBetterPercentile relative to all X-ray structuresPercentile relative to X-ray structures of similar resolution

More Asymmetric unit images

Molmil generated image of 3rig
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Molmil generated image of 3rig
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Molmil generated image of 3rig
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More Biological unit images

Molmil generated image of 3rig
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Molmil generated image of 3rig
rotated about x axis by 90°
Molmil generated image of 3rig
rotated about y axis by 90°
(*)In the case of coarse surface representation, the asymmetric unit is shown as red ribbon representation.
Coordinate files for Biological unit (3rig.pdb1.gz [89.2 KB])
Coordinate files for Biological unit (3rig.pdb2.gz [89.7 KB])