3RFN

Epitope backbone grafting by computational design for improved presentation of linear epitopes on scaffold proteins

3RFN の概要

• エントリーDOI: 10.2210/pdb3rfn/pdb
• 分子名称: BB_1wnu_001, ZINC ION (3 entities in total)
• 機能のキーワード: protein grafting, flexible backbone design, epitope-scaffold, hiv, immunogen design, de novo protein
• 由来する生物種: Pyrococcus horikoshii; 詳細
• 細胞内の位置: Cytoplasm : O58307
• タンパク質・核酸の鎖数: 1
• 化学式量合計: 18211.44

構造登録者

Azoitei, M.L.,Ban, Y.A.,Julien, J.P.,Bryson, S.,Schroeter, A.,Kalyuzhniy, O.,Porter, J.R.,Adachi, Y.,Baker, D.,Szabo, E.,Pai, E.F.,Schief, W.R. (登録日: 2011-04-06, 公開日: 2011-11-09, 最終更新日: 2023-09-13)

• 主引用文献: Azoitei, M.L.,Ban, Y.E.,Julien, J.P.,Bryson, S.,Schroeter, A.,Kalyuzhniy, O.,Porter, J.R.,Adachi, Y.,Baker, D.,Pai, E.F.,Schief, W.R.; Computational design of high-affinity epitope scaffolds by backbone grafting of a linear epitope.; J.Mol.Biol., 415:175-192, 2012; PubMed: 22061265; DOI: 10.1016/j.jmb.2011.10.003

実験手法

X-RAY DIFFRACTION (1.8 Å)