3RDP

Crystal structure of thymidine kinase from herpes simplex virus type 1 in complex with N-METHYL-FHBT

3RDP の概要

• エントリーDOI: 10.2210/pdb3rdp/pdb
• 関連するPDBエントリー: 1E2H 1E2P 3F0T
• 分子名称: Thymidine kinase, SULFATE ION, 6-[(2R)-2-(fluoromethyl)-3-hydroxy-propyl]-1,5-dimethyl-pyrimidine-2,4-dione, ... (4 entities in total)
• 機能のキーワード: transferase, thymidine kinase, dna-synthesis, pet tracer, atp-binding, dna synthesis, early protein, nucleotide-binding
• 由来する生物種: Human herpesvirus 1 (HHV-1)
• タンパク質・核酸の鎖数: 2
• 化学式量合計: 72306.83

構造登録者

Pernot, L.,Perozzo, R.,Westermaier, Y.,Martic, M.,Ametamey, S.,Scapozza, L. (登録日: 2011-04-01, 公開日: 2011-08-03, 最終更新日: 2023-11-01)

• 主引用文献: Martic, M.,Pernot, L.,Westermaier, Y.,Perozzo, R.,Kraljevic, T.G.,Kristafor, S.,Raic-Malic, S.,Scapozza, L.,Ametamey, S.; Synthesis, crystal structure, and in vitro biological evaluation of C-6 pyrimidine derivatives: new lead structures for monitoring gene expression in vivo.; Nucleosides Nucleotides Nucleic Acids, 30:293-315, 2011; PubMed: 21623543; DOI: 10.1080/15257770.2011.581258

実験手法

X-RAY DIFFRACTION (2.8 Å)