3RAB

GPPNHP-BOUND RAB3A AT 2.0 A RESOLUTION

Summary for 3RAB

• Entry DOI: 10.2210/pdb3rab/pdb
• Descriptor: PROTEIN (RAB3A), MAGNESIUM ION, PHOSPHOAMINOPHOSPHONIC ACID-GUANYLATE ESTER, ... (4 entities in total)
• Functional Keywords: g protein, vesicular trafficking, gtp hydrolysis, rab protein, neurotransmitter release, hydrolase
• Biological source: Rattus norvegicus (Norway rat)
• Cellular location: Cell membrane; Lipid-anchor; Cytoplasmic side (Potential): P63012
• Total number of polymer chains: 1
• Total formula weight: 20201.64

Authors

Dumas, J.J.,Zhu, Z.,Connolly, J.L.,Lambright, D.G. (deposition date: 1998-11-16, release date: 1999-04-16, Last modification date: 2023-09-13)

Primary citation

Dumas, J.J.,Zhu, Z.,Connolly, J.L.,Lambright, D.G.
Structural basis of activation and GTP hydrolysis in Rab proteins.
Structure Fold.Des., 7:413-423, 1999

PubMed Abstract: Rab proteins comprise a large family of GTPases that regulate vesicle trafficking. Despite conservation of critical residues involved in nucleotide binding and hydrolysis, Rab proteins exhibit low sequence identity with other GTPases, and the structural basis for Rab function remains poorly characterized.

PubMed: 10196122
DOI: 10.1016/S0969-2126(99)80054-9

Experimental method

X-RAY DIFFRACTION (2 Å)