3RAB

GPPNHP-BOUND RAB3A AT 2.0 A RESOLUTION

3RAB の概要

• エントリーDOI: 10.2210/pdb3rab/pdb
• 分子名称: PROTEIN (RAB3A), MAGNESIUM ION, PHOSPHOAMINOPHOSPHONIC ACID-GUANYLATE ESTER, ... (4 entities in total)
• 機能のキーワード: g protein, vesicular trafficking, gtp hydrolysis, rab protein, neurotransmitter release, hydrolase
• 由来する生物種: Rattus norvegicus (Norway rat)
• 細胞内の位置: Cell membrane; Lipid-anchor; Cytoplasmic side (Potential): P63012
• タンパク質・核酸の鎖数: 1
• 化学式量合計: 20201.64

構造登録者

Dumas, J.J.,Zhu, Z.,Connolly, J.L.,Lambright, D.G. (登録日: 1998-11-16, 公開日: 1999-04-16, 最終更新日: 2023-09-13)

主引用文献

Dumas, J.J.,Zhu, Z.,Connolly, J.L.,Lambright, D.G.
Structural basis of activation and GTP hydrolysis in Rab proteins.
Structure Fold.Des., 7:413-423, 1999

PubMed Abstract: Rab proteins comprise a large family of GTPases that regulate vesicle trafficking. Despite conservation of critical residues involved in nucleotide binding and hydrolysis, Rab proteins exhibit low sequence identity with other GTPases, and the structural basis for Rab function remains poorly characterized.

PubMed: 10196122
DOI: 10.1016/S0969-2126(99)80054-9

実験手法

X-RAY DIFFRACTION (2 Å)