3R92
Discovery of a macrocyclic o-aminobenzamide Hsp90 inhibitor with heterocyclic tether that shows extended biomarker activity and in vivo efficacy in a mouse xenograft model.
3R92 の概要
エントリーDOI | 10.2210/pdb3r92/pdb |
分子名称 | Heat shock protein HSP 90-alpha, (3aR)-13,13,16-trimethyl-15-oxo-1,2,3,3a,4,5,12,14,15,17,18,19-dodecahydro-13H-10,6-(metheno)pyrrolo[2',1':3,4][1,4,9]triazacyclotetradecino[9,8-a]indole-7-carboxamide (3 entities in total) |
機能のキーワード | chaperone, atp binding domain, atp-binding, nucleotide-binding, phosphoprotein, stress response, chaperone-chaperone inhibitor complex, chaperone/chaperone inhibitor |
由来する生物種 | Homo sapiens (human) |
タンパク質・核酸の鎖数 | 1 |
化学式量合計 | 25847.14 |
構造登録者 | Zapf, C.W.,Bloom, J.D.,McBean, J.L.,Dushin, R.G.,Golas, J.M.,Liu, H.,Lucas, J.,Boschelli, F.,Vogan, E.M.,Levin, J.I. (登録日: 2011-03-24, 公開日: 2011-06-08, 最終更新日: 2024-02-21) |
主引用文献 | Zapf, C.W.,Bloom, J.D.,McBean, J.L.,Dushin, R.G.,Golas, J.M.,Liu, H.,Lucas, J.,Boschelli, F.,Vogan, E.,Levin, J.I. Discovery of a macrocyclic o-aminobenzamide Hsp90 inhibitor with heterocyclic tether that shows extended biomarker activity and in vivo efficacy in a mouse xenograft model. Bioorg.Med.Chem.Lett., 21:3627-3631, 2011 Cited by PubMed: 21605975DOI: 10.1016/j.bmcl.2011.04.102 主引用文献が同じPDBエントリー |
実験手法 | X-RAY DIFFRACTION (1.5801 Å) |
構造検証レポート
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