3R91
Macrocyclic lactams as potent Hsp90 inhibitors with excellent tumor exposure and extended biomarker activity.
3R91 の概要
エントリーDOI | 10.2210/pdb3r91/pdb |
分子名称 | Heat shock protein HSP 90-alpha, (6S)-4,6,15,15,18-pentamethyl-5,17-dioxo-2,3,4,5,6,7,14,15,16,17-decahydro-1H-12,8-(metheno)[1,4,9]triazacyclotetradecino[9,8-a]indole-9-carboxamide (3 entities in total) |
機能のキーワード | chaperone, atp binding domain, atp-binding, nucleotide-binding, phosphoprotein, stress response, chaperone-chaperone inhibitor complex, chaperone/chaperone inhibitor |
由来する生物種 | Homo sapiens (human) |
細胞内の位置 | Cytoplasm: P07900 |
タンパク質・核酸の鎖数 | 1 |
化学式量合計 | 25849.11 |
構造登録者 | Zapf, C.W.,Bloom, J.D.,McBean, J.L.,Dushin, R.G.,Nittoli, T.,Otteng, M.,Ingalls, C.,Golas, J.M.,Liu, H.,Lucas, J.,Boschelli, F.,Vogan, E.,Hu, Y.,Levin, J.I. (登録日: 2011-03-24, 公開日: 2011-05-11, 最終更新日: 2023-09-13) |
主引用文献 | Zapf, C.W.,Bloom, J.D.,McBean, J.L.,Dushin, R.G.,Nittoli, T.,Otteng, M.,Ingalls, C.,Golas, J.M.,Liu, H.,Lucas, J.,Boschelli, F.,Hu, Y.,Vogan, E.,Levin, J.I. Macrocyclic lactams as potent Hsp90 inhibitors with excellent tumor exposure and extended biomarker activity. Bioorg.Med.Chem.Lett., 21:3411-3416, 2011 Cited by PubMed: 21515049DOI: 10.1016/j.bmcl.2011.03.112 主引用文献が同じPDBエントリー |
実験手法 | X-RAY DIFFRACTION (1.579 Å) |
構造検証レポート
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