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3R5W

Structure of Ddn, the Deazaflavin-dependent nitroreductase from Mycobacterium tuberculosis involved in bioreductive activation of PA-824, with co-factor F420

Summary for 3R5W
Entry DOI10.2210/pdb3r5w/pdb
Related3R5L 3R5P 3R5R 3R5Y 3R5Z
DescriptorDeazaflavin-dependent nitroreductase, COENZYME F420 (3 entities in total)
Functional Keywordspa-824, opc-67683, nitroimidazoles, split barrel-like fold; duf385, deazaflavin-dependent nitroreductase, f420, oxidoreductase
Biological sourceMycobacterium tuberculosis
Total number of polymer chains10
Total formula weight135301.77
Authors
Primary citationCellitti, S.E.,Shaffer, J.,Jones, D.H.,Mukherjee, T.,Gurumurthy, M.,Bursulaya, B.,Boshoff, H.I.,Choi, I.,Nayyar, A.,Lee, Y.S.,Cherian, J.,Niyomrattanakit, P.,Dick, T.,Manjunatha, U.H.,Barry, C.E.,Spraggon, G.,Geierstanger, B.H.
Structure of Ddn, the deazaflavin-dependent nitroreductase from Mycobacterium tuberculosis involved in bioreductive activation of PA-824.
Structure, 20:101-112, 2012
Cited by
PubMed: 22244759
DOI: 10.1016/j.str.2011.11.001
PDB entries with the same primary citation
Experimental method
X-RAY DIFFRACTION (1.786 Å)
Structure validation

217705

건을2024-03-27부터공개중

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