3R17
hCarbonic anhydrase II bound to N-(2-fluoro.4-sulfamoylphenyl)-2-(thiophen-2-yl) acetamide
Summary for 3R17
| Entry DOI | 10.2210/pdb3r17/pdb |
| Related | 3R16 |
| Descriptor | Carbonic anhydrase 2, ZINC ION, GLYCEROL, ... (6 entities in total) |
| Functional Keywords | reversible hydration of carbondioxide, lyase |
| Biological source | Homo sapiens (human) |
| Cellular location | Cytoplasm: P00918 |
| Total number of polymer chains | 1 |
| Total formula weight | 29574.73 |
| Authors | Biswas, S.,McKenna, R. (deposition date: 2011-03-09, release date: 2011-05-25, Last modification date: 2024-02-21) |
| Primary citation | Biswas, S.,Aggarwal, M.,Guzel, O.,Scozzafava, A.,McKenna, R.,Supuran, C.T. Conformational variability of different sulfonamide inhibitors with thienyl-acetamido moieties attributes to differential binding in the active site of cytosolic human carbonic anhydrase isoforms. Bioorg.Med.Chem., 19:3732-3738, 2011 Cited by PubMed: 21620713DOI: 10.1016/j.bmc.2011.05.006 PDB entries with the same primary citation |
| Experimental method | X-RAY DIFFRACTION (1.7 Å) |
Structure validation
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