3R16

Human CAII bound to N-(4-sulfamoylphenyl)-2-(thiophen-2-yl) acetamide

Summary for 3R16

• Entry DOI: 10.2210/pdb3r16/pdb
• Related: 3R17
• Descriptor: Carbonic anhydrase 2, ZINC ION, GLYCEROL, ... (6 entities in total)
• Functional Keywords: reversible hydration of carbondioxide, lyase
• Biological source: Homo sapiens (human)
• Cellular location: Cytoplasm: P00918
• Total number of polymer chains: 1
• Total formula weight: 29556.74

Authors

Biswas, S.,McKenna, R.,Supuran, C.T. (deposition date: 2011-03-09, release date: 2011-05-25, Last modification date: 2024-02-21)

• Primary citation: Biswas, S.,Aggarwal, M.,Guzel, O.,Scozzafava, A.,McKenna, R.,Supuran, C.T.; Conformational variability of different sulfonamide inhibitors with thienyl-acetamido moieties attributes to differential binding in the active site of cytosolic human carbonic anhydrase isoforms.; Bioorg.Med.Chem., 19:3732-3738, 2011; PubMed: 21620713; DOI: 10.1016/j.bmc.2011.05.006

Experimental method

X-RAY DIFFRACTION (1.6 Å)