3QYO
Sensitivity of receptor internal motions to ligand binding affinity and kinetic off-rate
Summary for 3QYO
Entry DOI | 10.2210/pdb3qyo/pdb |
Related | 3QYL |
Descriptor | Dihydrofolate reductase, quinazoline-2,4-diamine, NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE, ... (5 entities in total) |
Functional Keywords | rossmann fold, reductase, oxidoreductase |
Biological source | Escherichia coli K-12 |
Total number of polymer chains | 1 |
Total formula weight | 19246.55 |
Authors | Collins, E.J.,Lee, A.L.,Carroll, M.J.,Mauldin, R.V.,Gromova, A.V.,Singleton, S.F. (deposition date: 2011-03-03, release date: 2012-01-18, Last modification date: 2024-02-21) |
Primary citation | Carroll, M.J.,Mauldin, R.V.,Gromova, A.V.,Singleton, S.F.,Collins, E.J.,Lee, A.L. Evidence for dynamics in proteins as a mechanism for ligand dissociation. Nat.Chem.Biol., 8:246-252, 2012 Cited by PubMed: 22246400DOI: 10.1038/nchembio.769 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.09 Å) |
Structure validation
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