3QWI

Crystal structure of a 17beta-hydroxysteroid dehydrogenase (holo form) from fungus Cochliobolus lunatus in complex with NADPH and coumestrol

Summary for 3QWI

Entry DOI	10.2210/pdb3qwi/pdb
Related	3IS3 3ITD 3QWF 3QWH
Descriptor	17beta-hydroxysteroid dehydrogenase, NADP NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE, Coumestrol, ... (5 entities in total)
Functional Keywords	17beta-hydroxysteroid dehydrogenase, short chain dehydrogenase/reductase, phytoestrogens, flavonoid, rossmann fold, cytosol, oxidoreductase-oxidoreductase inhibitor complex, oxidoreductase/oxidoreductase inhibitor
Biological source	Cochliobolus lunatus
Total number of polymer chains	4
Total formula weight	120083.07
Authors	Cassetta, A.,Lamba, D.,Krastanova, I.,Stojan, J.,Lanisnik Rizner, T.,Kristan, K.,Brunskole, M. (deposition date: 2011-02-28, release date: 2012-01-18, Last modification date: 2023-09-13)
Primary citation	Cassetta, A.,Krastanova, I.,Kristan, K.,Brunskole Svegelj, M.,Lamba, D.,Lanisnik Rizner, T.,Stojan, J. Structural studies on the flavonoid inhibition of a fungal 17Beta-Hydroxysteroid dehydrogenase Biochem.J., 441:151-160, 2012 Cited by PubMed: 21929506 DOI: 10.1042/BJ20110567 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.5 Å)

Structure validation