3QWH

Crystal structure of the 17beta-hydroxysteroid dehydrogenase from Cochliobolus lunatus in complex with NADPH and kaempferol

Summary for 3QWH

Entry DOI	10.2210/pdb3qwh/pdb
Related	3IS3 3ITD 3QWF
Descriptor	17beta-hydroxysteroid dehydrogenase, NADP NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE, 3,5,7-TRIHYDROXY-2-(4-HYDROXYPHENYL)-4H-CHROMEN-4-ONE, ... (5 entities in total)
Functional Keywords	17beta-hydroxysteroid dehydrogenase, short chain dehydrogenase/reductase, phytoestrogens, flavonoids, rossmann fold, cytosol, oxidoreductase-oxidoreductase inhibitor complex, oxidoreductase/oxidoreductase inhibitor
Biological source	Cochliobolus lunatus
Total number of polymer chains	4
Total formula weight	119684.63
Authors	Cassetta, A.,Lamba, D.,Krastanova, I.,Stojan, J.,Rizner, T.L.,Kristan, K.,Brunskole, M. (deposition date: 2011-02-28, release date: 2012-03-21, Last modification date: 2023-09-13)
Primary citation	Cassetta, A.,Stojan, J.,Krastanova, I.,Kristan, K.,Brunskole Svegelj, M.,Lamba, D.,Rizner, T.L. Structural basis for inhibition of 17 beta-hydroxysteroid dehydrogenases by phytoestrogens: The case of fungal 17 beta-HSDcl. J. Steroid Biochem. Mol. Biol., 171:80-93, 2017 Cited by PubMed: 28259640 DOI: 10.1016/j.jsbmb.2017.02.020 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.62 Å)

Structure validation