3QWH

Crystal structure of the 17beta-hydroxysteroid dehydrogenase from Cochliobolus lunatus in complex with NADPH and kaempferol

3QWH の概要

• エントリーDOI: 10.2210/pdb3qwh/pdb
• 関連するPDBエントリー: 3IS3 3ITD 3QWF
• 分子名称: 17beta-hydroxysteroid dehydrogenase, NADP NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE, 3,5,7-TRIHYDROXY-2-(4-HYDROXYPHENYL)-4H-CHROMEN-4-ONE, ... (5 entities in total)
• 機能のキーワード: 17beta-hydroxysteroid dehydrogenase, short chain dehydrogenase/reductase, phytoestrogens, flavonoids, rossmann fold, cytosol, oxidoreductase-oxidoreductase inhibitor complex, oxidoreductase/oxidoreductase inhibitor
• 由来する生物種: Cochliobolus lunatus
• タンパク質・核酸の鎖数: 4
• 化学式量合計: 119684.63

構造登録者

Cassetta, A.,Lamba, D.,Krastanova, I.,Stojan, J.,Rizner, T.L.,Kristan, K.,Brunskole, M. (登録日: 2011-02-28, 公開日: 2012-03-21, 最終更新日: 2023-09-13)

• 主引用文献: Cassetta, A.,Stojan, J.,Krastanova, I.,Kristan, K.,Brunskole Svegelj, M.,Lamba, D.,Rizner, T.L.; Structural basis for inhibition of 17 beta-hydroxysteroid dehydrogenases by phytoestrogens: The case of fungal 17 beta-HSDcl.; J. Steroid Biochem. Mol. Biol., 171:80-93, 2017; PubMed: 28259640; DOI: 10.1016/j.jsbmb.2017.02.020

実験手法

X-RAY DIFFRACTION (2.62 Å)