3QUV

Crystal structure of a tRNA-guanine-N1-methyltransferase from Mycobacterium abscessus

3QUV の概要

• エントリーDOI: 10.2210/pdb3quv/pdb
• 分子名称: tRNA (guanine-N(1)-)-methyltransferase, 1,2-ETHANEDIOL (3 entities in total)
• 機能のキーワード: sssgcid, seattle structural genomics center for infectious disease, ssgcid, trna methyltransferase, trmd, s-adenosyl-methionine, s-adenosyl-homocysteine, sam, sah, chronic lung disease, protein knot, 3(1) trefoil knot, domain swap, transferase
• 由来する生物種: Mycobacterium abscessus
• 細胞内の位置: Cytoplasm : B1MDI3
• タンパク質・核酸の鎖数: 2
• 化学式量合計: 53425.95

構造登録者

Seattle Structural Genomics Center for Infectious Disease (SSGCID) (登録日: 2011-02-24, 公開日: 2011-03-16, 最終更新日: 2023-09-13)

• 主引用文献: Baugh, L.,Phan, I.,Begley, D.W.,Clifton, M.C.,Armour, B.,Dranow, D.M.,Taylor, B.M.,Muruthi, M.M.,Abendroth, J.,Fairman, J.W.,Fox, D.,Dieterich, S.H.,Staker, B.L.,Gardberg, A.S.,Choi, R.,Hewitt, S.N.,Napuli, A.J.,Myers, J.,Barrett, L.K.,Zhang, Y.,Ferrell, M.,Mundt, E.,Thompkins, K.,Tran, N.,Lyons-Abbott, S.,Abramov, A.,Sekar, A.,Serbzhinskiy, D.,Lorimer, D.,Buchko, G.W.,Stacy, R.,Stewart, L.J.,Edwards, T.E.,Van Voorhis, W.C.,Myler, P.J.; Increasing the structural coverage of tuberculosis drug targets.; Tuberculosis (Edinb), 95:142-148, 2015; PubMed: 25613812; DOI: 10.1016/j.tube.2014.12.003

実験手法

X-RAY DIFFRACTION (1.7 Å)