3QU8

Crystal structure of a human cytochrome P450 2B6 (Y226H/K262R) in complex with the inhibitor 4-(4-Nitrobenzyl)pyridine.

3QU8 の概要

• エントリーDOI: 10.2210/pdb3qu8/pdb
• 関連するPDBエントリー: 3IBD 3QOA
• 分子名称: Cytochrome P450 2B6, PROTOPORPHYRIN IX CONTAINING FE, 4-(4-nitrobenzyl)pyridine, ... (5 entities in total)
• 機能のキーワード: p450, cytochrome p450 2b6, monooxygenase, membrane protein, cyp2b6, endoplasmic reticulum, heme, iron, membrane, metal binding, microsome, phosphoprotein, oxidoreductase-oxidoreductase inhibitor complex, oxidoreductase/oxidoreductase inhibitor
• 由来する生物種: Homo sapiens (human)
• 細胞内の位置: Endoplasmic reticulum membrane; Peripheral membrane protein: P20813
• タンパク質・核酸の鎖数: 6
• 化学式量合計: 336602.63

構造登録者

Shah, M.B.,Pascual, J.,Stout, C.D.,Halpert, J.R. (登録日: 2011-02-23, 公開日: 2011-09-21, 最終更新日: 2023-09-13)

• 主引用文献: Shah, M.B.,Pascual, J.,Zhang, Q.,Stout, C.D.,Halpert, J.R.; Structures of Cytochrome P450 2B6 Bound to 4-Benzylpyridine and 4-(4-Nitrobenzyl)pyridine: Insight into Inhibitor Binding and Rearrangement of Active Site Side Chains.; Mol.Pharmacol., 80:1047-1055, 2011; PubMed: 21875942; DOI: 10.1124/mol.111.074427

実験手法

X-RAY DIFFRACTION (2.8 Å)