3QTF

Design and SAR of macrocyclic Hsp90 inhibitors with increased metabolic stability and potent cell-proliferation activity

3QTF の概要

• エントリーDOI: 10.2210/pdb3qtf/pdb
• 分子名称: Heat shock protein HSP 90-alpha, (6S)-6,15,15,18-tetramethyl-17-oxo-2,3,4,5,6,7,14,15,16,17-decahydro-1H-8,12-(metheno)[1,4,9]triazacyclotetradecino[9,8-a]indole-9-carboxamide, DIMETHYL SULFOXIDE, ... (4 entities in total)
• 機能のキーワード: chaperone, atp binding domain, atp-binding, nucleotide-binding, phosphoprotein, stress response, chaperone-chaperone inhibitor complex, chaperone/chaperone inhibitor
• 由来する生物種: Homo sapiens (human)
• 細胞内の位置: Cytoplasm: P07900
• タンパク質・核酸の鎖数: 1
• 化学式量合計: 25899.24

構造登録者

Zapf, C.W.,Bloom, J.D.,McBean, J.L.,Dushin, R.G.,Nittoli, T.,Ingalls, C.,Sutherland, A.G.,Sonye, J.P.,Eid, C.N.,Golas, J.,Liu, H.,Boschelli, F.,Hu, Y.,Vogan, E.M.,Levin, J.I. (登録日: 2011-02-22, 公開日: 2011-04-06, 最終更新日: 2024-02-21)

• 主引用文献: Zapf, C.W.,Bloom, J.D.,McBean, J.L.,Dushin, R.G.,Nittoli, T.,Ingalls, C.,Sutherland, A.G.,Sonye, J.P.,Eid, C.N.,Golas, J.,Liu, H.,Boschelli, F.,Hu, Y.,Vogan, E.,Levin, J.I.; Design and SAR of macrocyclic Hsp90 inhibitors with increased metabolic stability and potent cell-proliferation activity.; Bioorg.Med.Chem.Lett., 21:2278-2282, 2011; PubMed: 21420297; DOI: 10.1016/j.bmcl.2011.02.101

実験手法

X-RAY DIFFRACTION (1.5703 Å)