3QSB
Structure of E. coli polIIIbeta with (Z)-5-(1-((4'-Fluorobiphenyl-4-yl)methoxyimino)butyl)-2,2-dimethyl-4,6-dioxocyclohexanecarbonitrile
Summary for 3QSB
Entry DOI | 10.2210/pdb3qsb/pdb |
Related | 1MMI 2POL |
Descriptor | DNA polymerase III subunit beta, (1R,5R)-5-{(1Z)-N-[(4'-fluorobiphenyl-4-yl)methoxy]butanimidoyl}-2,2-dimethyl-4,6-dioxocyclohexanecarbonitrile, ... (4 entities in total) |
Functional Keywords | dna replication, sliding clamp, dnan, transferase-transferase inhibitor complex, transferase/transferase inhibitor |
Biological source | Escherichia coli More |
Cellular location | Cytoplasm : P0A988 P0A988 |
Total number of polymer chains | 2 |
Total formula weight | 82146.02 |
Authors | Wijffels, G.,Johnson, W.M.,Oakley, A.J.,Turner, K.,Epa, V.C.,Briscoe, S.J.,Polley, M.,Liepa, A.J.,Hofmann, A.,Buchardt, J.,Christensen, C.,Prosselkov, P.,Dalrymple, B.P.,Alewood, P.F.,Jennings, P.A.,Dixon, N.E.,Winkler, D.A. (deposition date: 2011-02-20, release date: 2011-06-08, Last modification date: 2023-12-06) |
Primary citation | Wijffels, G.,Johnson, W.M.,Oakley, A.J.,Turner, K.,Epa, V.C.,Briscoe, S.J.,Polley, M.,Liepa, A.J.,Hofmann, A.,Buchardt, J.,Christensen, C.,Prosselkov, P.,Dalrymple, B.P.,Alewood, P.F.,Jennings, P.A.,Dixon, N.E.,Winkler, D.A. Binding inhibitors of the bacterial sliding clamp by design J.Med.Chem., 54:4831-4838, 2011 Cited by PubMed: 21604761DOI: 10.1021/jm2004333 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (1.9 Å) |
Structure validation
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