3QP5

Crystal structure of CviR bound to antagonist chlorolactone (CL)

Summary for 3QP5

Entry DOI	10.2210/pdb3qp5/pdb
Related	3QP1 3QP2 3QP4 3QP6 3QP7 3QP8
Descriptor	CviR transcriptional regulator, 4-(4-chlorophenoxy)-N-[(3S)-2-oxotetrahydrofuran-3-yl]butanamide (2 entities in total)
Functional Keywords	quorum sensing, agonist, antagonist, luxr, acylated homoserine lactone, transcription factor, dna binding protein, ligand binding domain, signal receptor, quorum sensing transcription factor, chlorolactone (cl), transcription
Biological source	Chromobacterium violaceum
Total number of polymer chains	4
Total formula weight	120203.01
Authors	Chen, G.,Swem, L.,Swem, D.,Stauff, D.,O'Loughlin, C.,Jeffrey, P.,Bassler, B.,Hughson, F. (deposition date: 2011-02-11, release date: 2011-03-30, Last modification date: 2023-09-13)
Primary citation	Chen, G.,Swem, L.R.,Swem, D.L.,Stauff, D.L.,O'Loughlin, C.T.,Jeffrey, P.D.,Bassler, B.L.,Hughson, F.M. A strategy for antagonizing quorum sensing. Mol.Cell, 42:199-209, 2011 Cited by PubMed: 21504831 DOI: 10.1016/j.molcel.2011.04.003 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (3.249 Å)

Structure validation