3QMT
Crystal structure of the mutant V182A,Y206F of orotidine 5'-monophosphate decarboxylase from Methanobacterium thermoautotrophicum complexed with the inhibitor BMP
Summary for 3QMT
Entry DOI | 10.2210/pdb3qmt/pdb |
Related | 3LTP |
Descriptor | Orotidine 5'-phosphate decarboxylase, 6-HYDROXYURIDINE-5'-PHOSPHATE, GLYCEROL, ... (4 entities in total) |
Functional Keywords | tim barrel fold, orotidine 5'-monophosphate decarboxylase, inhibitor bmp, lyase-lyase inhibitor complex, lyase/lyase inhibitor |
Biological source | Methanothermobacter thermautotrophicus str. Delta H |
Total number of polymer chains | 2 |
Total formula weight | 50453.75 |
Authors | Fedorov, A.A.,Fedorov, E.V.,Desai, B.,Gerlt, J.A.,Almo, S.C. (deposition date: 2011-02-05, release date: 2012-02-08, Last modification date: 2023-09-13) |
Primary citation | Desai, B.J.,Wood, B.M.,Fedorov, A.A.,Fedorov, E.V.,Goryanova, B.,Amyes, T.L.,Richard, J.P.,Almo, S.C.,Gerlt, J.A. Conformational changes in orotidine 5'-monophosphate decarboxylase: a structure-based explanation for how the 5'-phosphate group activates the enzyme. Biochemistry, 51:8665-8678, 2012 Cited by PubMed: 23030629DOI: 10.1021/bi301188k PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (1.3202 Å) |
Structure validation
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