3QMD

Structural Basis of Selective Binding of Nonmethylated CpG Islands by the CXXC Domain of CFP1

3QMD の概要

• エントリーDOI: 10.2210/pdb3qmd/pdb
• 関連するPDBエントリー: 3QMB 3QMC 3QMG 3QMH 3QMI
• 分子名称: CpG-binding protein, DNA (5'-D(*GP*CP*CP*AP*AP*CP*GP*AP*TP*GP*GP*C)-3'), DNA (5'-D(*GP*CP*CP*AP*TP*CP*GP*TP*TP*GP*GP*C)-3'), ... (5 entities in total)
• 機能のキーワード: structural genomics consortium, sgc, cxxc-type zn finger, dna binding, unmethylated cpg motifs, nucleus speckle, dna binding protein-dna complex, dna binding protein/dna
• 由来する生物種: Homo sapiens (human); 詳細
• 細胞内の位置: Nucleus speckle : Q9P0U4
• タンパク質・核酸の鎖数: 3
• 化学式量合計: 16985.56

構造登録者

Lam, R.,Xu, C.,Bian, C.B.,Kania, J.,Bountra, C.,Weigelt, J.,Arrowsmith, C.H.,Edwards, A.M.,Bochkarev, A.,Min, J.,Structural Genomics Consortium (SGC) (登録日: 2011-02-04, 公開日: 2011-02-23, 最終更新日: 2023-09-13)

• 主引用文献: Xu, C.,Bian, C.,Lam, R.,Dong, A.,Min, J.; The structural basis for selective binding of non-methylated CpG islands by the CFP1 CXXC domain.; Nat Commun, 2:227-227, 2011; PubMed: 21407193; DOI: 10.1038/ncomms1237

実験手法

X-RAY DIFFRACTION (1.9 Å)