3QKL
Spirochromane Akt Inhibitors
Summary for 3QKL
Entry DOI | 10.2210/pdb3qkl/pdb |
Related | 3OCB 3QKK 3QKM |
Descriptor | RAC-alpha serine/threonine-protein kinase, GSK-3 beta peptide, N-{(2S)-3-[(3S)-8',9'-dihydro-1H,3'H-spiro[piperidine-3,7'-pyrano[3,2-e]indazol]-1-yl]-2-hydroxypropyl}-N-(2-ethoxyethyl)-2,6-dimethylbenzenesulfonamide, ... (4 entities in total) |
Functional Keywords | kinase domain, transferase-transferase inhibitor complex, transferase/transferase inhibitor |
Biological source | Homo sapiens (human) |
Cellular location | Cytoplasm: P31749 |
Total number of polymer chains | 2 |
Total formula weight | 41146.91 |
Authors | Kallan, N.C.,Spencer, K.L.,Blake, J.F.,Xu, R.,Heizer, J.,Bencsik, J.R.,Mitchell, I.S.,Gloor, S.L.,Martinson, M.,Risom, T.,Gross, S.D.,Morales, T.,Vigers, G.P.A.,Brandhuber, B.J.,Skelton, N.J. (deposition date: 2011-02-01, release date: 2011-03-30, Last modification date: 2011-07-13) |
Primary citation | Kallan, N.C.,Spencer, K.L.,Blake, J.F.,Xu, R.,Heizer, J.,Bencsik, J.R.,Mitchell, I.S.,Gloor, S.L.,Martinson, M.,Risom, T.,Gross, S.D.,Morales, T.H.,Wu, W.I.,Vigers, G.P.,Brandhuber, B.J.,Skelton, N.J. Discovery and SAR of spirochromane Akt inhibitors. Bioorg.Med.Chem.Lett., 21:2410-2414, 2011 Cited by PubMed: 21392984DOI: 10.1016/j.bmcl.2011.02.073 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (1.9 Å) |
Structure validation
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