3QKD
Crystal structure of Bcl-xL in complex with a Quinazoline sulfonamide inhibitor
Summary for 3QKD
Entry DOI | 10.2210/pdb3qkd/pdb |
Descriptor | Bcl-2-like protein 1, (R)-N-(7-(4-((4'-chlorobiphenyl-2-yl)methyl)piperazin-1-yl)quinazolin-4-yl)-4-(4-(dimethylamino)-1-(phenylthio)butan-2-ylamino)-3-nitrobenzenesulfonamide, CHLORIDE ION, ... (5 entities in total) |
Functional Keywords | bcl-2 family fold, apoptosis-inhibitor complex, apoptosis/inhibitor |
Biological source | Homo sapiens (human) |
Cellular location | Mitochondrion membrane; Single-pass membrane protein (By similarity): Q07817 |
Total number of polymer chains | 2 |
Total formula weight | 43412.29 |
Authors | Czabotar, P.E.,Smith, B.J. (deposition date: 2011-01-31, release date: 2011-04-06, Last modification date: 2023-11-01) |
Primary citation | Sleebs, B.E.,Czabotar, P.E.,Fairbrother, W.J.,Fairlie, W.D.,Flygare, J.A.,Huang, D.C.,Kersten, W.J.,Koehler, M.F.,Lessene, G.,Lowes, K.,Parisot, J.P.,Smith, B.J.,Smith, M.L.,Souers, A.J.,Street, I.P.,Yang, H.,Baell, J.B. Quinazoline sulfonamides as dual binders of the proteins B-cell lymphoma 2 and B-cell lymphoma extra long with potent proapoptotic cell-based activity. J.Med.Chem., 54:1914-1926, 2011 Cited by PubMed: 21366295DOI: 10.1021/jm101596e PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.02 Å) |
Structure validation
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