3QKD

Crystal structure of Bcl-xL in complex with a Quinazoline sulfonamide inhibitor

3QKD の概要

• エントリーDOI: 10.2210/pdb3qkd/pdb
• 分子名称: Bcl-2-like protein 1, (R)-N-(7-(4-((4'-chlorobiphenyl-2-yl)methyl)piperazin-1-yl)quinazolin-4-yl)-4-(4-(dimethylamino)-1-(phenylthio)butan-2-ylamino)-3-nitrobenzenesulfonamide, CHLORIDE ION, ... (5 entities in total)
• 機能のキーワード: bcl-2 family fold, apoptosis-inhibitor complex, apoptosis/inhibitor
• 由来する生物種: Homo sapiens (human)
• 細胞内の位置: Mitochondrion membrane; Single-pass membrane protein (By similarity): Q07817
• タンパク質・核酸の鎖数: 2
• 化学式量合計: 43412.29

構造登録者

Czabotar, P.E.,Smith, B.J. (登録日: 2011-01-31, 公開日: 2011-04-06, 最終更新日: 2023-11-01)

• 主引用文献: Sleebs, B.E.,Czabotar, P.E.,Fairbrother, W.J.,Fairlie, W.D.,Flygare, J.A.,Huang, D.C.,Kersten, W.J.,Koehler, M.F.,Lessene, G.,Lowes, K.,Parisot, J.P.,Smith, B.J.,Smith, M.L.,Souers, A.J.,Street, I.P.,Yang, H.,Baell, J.B.; Quinazoline sulfonamides as dual binders of the proteins B-cell lymphoma 2 and B-cell lymphoma extra long with potent proapoptotic cell-based activity.; J.Med.Chem., 54:1914-1926, 2011; PubMed: 21366295; DOI: 10.1021/jm101596e

実験手法

X-RAY DIFFRACTION (2.02 Å)