3QK0

Crystal structure of PI3K-gamma in complex with benzothiazole 82

3QK0 の概要

• エントリーDOI: 10.2210/pdb3qk0/pdb
• 関連するPDBエントリー: 3QJZ
• 分子名称: Phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit gamma isoform, SULFATE ION, N-[6-(6-chloro-5-{[(4-fluorophenyl)sulfonyl]amino}pyridin-3-yl)-1,3-benzothiazol-2-yl]acetamide, ... (4 entities in total)
• 機能のキーワード: p110, transferase, kinase, inhibitor, atp-binding, p84, p101, transferase-transferase inhibitor complex, transferase/transferase inhibitor
• 由来する生物種: Homo sapiens (human)
• タンパク質・核酸の鎖数: 1
• 化学式量合計: 110589.18

構造登録者

Whittington, D.A.,Tang, J.,Yakowec, P. (登録日: 2011-01-31, 公開日: 2011-03-30, 最終更新日: 2023-09-13)

• 主引用文献: D'Angelo, N.D.,Kim, T.S.,Andrews, K.,Booker, S.K.,Caenepeel, S.,Chen, K.,D'Amico, D.,Freeman, D.,Jiang, J.,Liu, L.,McCarter, J.D.,San Miguel, T.,Mullady, E.L.,Schrag, M.,Subramanian, R.,Tang, J.,Wahl, R.C.,Wang, L.,Whittington, D.A.,Wu, T.,Xi, N.,Xu, Y.,Yakowec, P.,Yang, K.,Zalameda, L.P.,Zhang, N.,Hughes, P.,Norman, M.H.; Discovery and Optimization of a Series of Benzothiazole Phosphoinositide 3-Kinase (PI3K)/Mammalian Target of Rapamycin (mTOR) Dual Inhibitors.; J.Med.Chem., 54:1789-1811, 2011; PubMed: 21332118; DOI: 10.1021/jm1014605

実験手法

X-RAY DIFFRACTION (2.85 Å)