3QIZ
Crystal Structure of BoNT/A LC complexed with Hydroxamate-based Inhibitor PT-2
3QIZ の概要
エントリーDOI | 10.2210/pdb3qiz/pdb |
関連するPDBエントリー | 3QIX 3QIY 3QJ0 |
分子名称 | Botulinum neurotoxin type A, ZINC ION, (2S,4R)-2-(2-{[3-(4-fluoro-3-methylphenyl)propyl](methyl)amino}ethyl)-4-(4-fluorophenyl)-N-hydroxy-4-methoxybutanamide, ... (5 entities in total) |
機能のキーワード | botulinum, bont, neurotoxin, toxin, hydroxamate, inhibitor, metalloprotease, protease, hydrolase-hydrolase inhibitor complex, hydrolase/hydrolase inhibitor |
由来する生物種 | Clostridium botulinum |
細胞内の位置 | Botulinum neurotoxin A light chain: Secreted. Botulinum neurotoxin A heavy chain: Secreted: A5HZZ9 |
タンパク質・核酸の鎖数 | 1 |
化学式量合計 | 49981.71 |
構造登録者 | |
主引用文献 | Thompson, A.A.,Jiao, G.S.,Kim, S.,Thai, A.,Cregar-Hernandez, L.,Margosiak, S.A.,Johnson, A.T.,Han, G.W.,O'Malley, S.,Stevens, R.C. Structural Characterization of Three Novel Hydroxamate-Based Zinc Chelating Inhibitors of the Clostridium botulinum Serotype A Neurotoxin Light Chain Metalloprotease Reveals a Compact Binding Site Resulting from 60/70 Loop Flexibility. Biochemistry, 50:4019-4028, 2011 Cited by PubMed: 21434688DOI: 10.1021/bi2001483 主引用文献が同じPDBエントリー |
実験手法 | X-RAY DIFFRACTION (2 Å) |
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