3QII

Crystal structure of tudor domain 2 of human PHD finger protein 20

3QII の概要

• エントリーDOI: 10.2210/pdb3qii/pdb
• 分子名称: PHD finger protein 20, UNKNOWN ATOM OR ION (3 entities in total)
• 機能のキーワード: tudor domain, phd finger, structural genomics, structural genomics consortium, sgc, transcription regulator
• 由来する生物種: Homo sapiens (human)
• 細胞内の位置: Nucleus : Q9BVI0
• タンパク質・核酸の鎖数: 1
• 化学式量合計: 9818.98

構造登録者

Li, Z.,Tempel, W.,Wernimont, A.K.,Chao, X.,Bian, C.,Lam, R.,Crombet, L.,Bountra, C.,Weigelt, J.,Arrowsmith, C.H.,Edwards, A.M.,Bochkarev, A.,Min, J.,Structural Genomics Consortium (SGC) (登録日: 2011-01-27, 公開日: 2011-02-09, 最終更新日: 2024-11-20)

主引用文献

Adams-Cioaba, M.A.,Li, Z.,Tempel, W.,Guo, Y.,Bian, C.,Li, Y.,Lam, R.,Min, J.
Crystal structures of the Tudor domains of human PHF20 reveal novel structural variations on the Royal Family of proteins.
Febs Lett., 586:859-865, 2012

PubMed Abstract: The human PHD finger protein 20 (PHF20) is a putative transcription factor. While little is known about its cognate cellular role, antibodies against PHF20 are present in sera from patients with hepatocellular carcinoma, glioblastoma and childhood medulloblastula. PHF20 comprises two N-terminal Tudor domains, a central C2H2-link zinc finger domain and a C-terminal zinc-binding PHD domain, and is a component of some MLL methyltransferase complexes. Here, we report the crystal structures of the N-terminal Tudor domains of PHF20 and highlight the novel structural features of each domain. We also confirm previous studies suggesting that the second Tudor domain of PHF20 exhibits preference for dimethylated histone substrates.

PubMed: 22449972
DOI: 10.1016/j.febslet.2012.02.012

実験手法

X-RAY DIFFRACTION (2.3 Å)