3QFV

MRCK beta in complex with TPCA-1

Summary for 3QFV

• Entry DOI: 10.2210/pdb3qfv/pdb
• Related: 3MY4
• Descriptor: CDC42BPB protein, 2-(carbamoylamino)-5-(4-fluorophenyl)thiophene-3-carboxamide, 1,2-ETHANEDIOL, ... (6 entities in total)
• Functional Keywords: protein kinase domain of mrck beta in complex with tpca-1, transferase-transferase inhibitor complex, transferase/transferase inhibitor
• Biological source: Homo sapiens (human)
• Total number of polymer chains: 2
• Total formula weight: 96314.24

Authors

Heikkila, T.J.,Wheatley, E.,Crighton, D.,Schroder, E.,Boakes, A.,Kaye, S.J.,Mezna, M.,Pang, L.,Rushbrooke, M.,Turnbull, A.,Olson, M.F. (deposition date: 2011-01-23, release date: 2011-10-12, Last modification date: 2024-02-21)

• Primary citation: Heikkila, T.,Wheatley, E.,Crighton, D.,Schroder, E.,Boakes, A.,Kaye, S.J.,Mezna, M.,Pang, L.,Rushbrooke, M.,Turnbull, A.,Olson, M.F.; Co-crystal structures of inhibitors with MRCK beta , a key regulator of tumor cell invasion.; Plos One, 6:e24825-e24825, 2011; PubMed: 21949762; DOI: 10.1371/journal.pone.0024825

Experimental method

X-RAY DIFFRACTION (2.65 Å)