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3QAR

Crystal structure of PI3K-gamma in complex with triazine-benzimidazole 32

Summary for 3QAR
Entry DOI10.2210/pdb3qar/pdb
Related3QAQ
DescriptorPhosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit gamma isoform, SULFATE ION, 1-(4-amino-6-methyl-1,3,5-triazin-2-yl)-N-(1H-pyrazol-3-yl)-1H-benzimidazol-2-amine, ... (4 entities in total)
Functional Keywordsinhibitor, p110, kinase, transferase, atp-binding, p84, p101, transferase-transferase inhibitor complex, transferase/transferase inhibitor
Biological sourceHomo sapiens (human)
Total number of polymer chains1
Total formula weight110419.56
Authors
Whittington, D.A.,Tang, J.,Yakowec, P. (deposition date: 2011-01-11, release date: 2011-03-30, Last modification date: 2023-09-13)
Primary citationPeterson, E.A.,Andrews, P.S.,Be, X.,Boezio, A.A.,Bush, T.L.,Cheng, A.C.,Coats, J.R.,Colletti, A.E.,Copeland, K.W.,Dupont, M.,Graceffa, R.,Grubinska, B.,Harmange, J.C.,Kim, J.L.,Mullady, E.L.,Olivieri, P.,Schenkel, L.B.,Stanton, M.K.,Teffera, Y.,Whittington, D.A.,Cai, T.,La, D.S.
Discovery of triazine-benzimidazoles as selective inhibitors of mTOR.
Bioorg.Med.Chem.Lett., 21:2064-2070, 2011
Cited by
PubMed: 21376583
DOI: 10.1016/j.bmcl.2011.02.007
PDB entries with the same primary citation
Experimental method
X-RAY DIFFRACTION (2.65 Å)
Structure validation

217705

数据于2024-03-27公开中

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