3QAR

Crystal structure of PI3K-gamma in complex with triazine-benzimidazole 32

3QAR の概要

• エントリーDOI: 10.2210/pdb3qar/pdb
• 関連するPDBエントリー: 3QAQ
• 分子名称: Phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit gamma isoform, SULFATE ION, 1-(4-amino-6-methyl-1,3,5-triazin-2-yl)-N-(1H-pyrazol-3-yl)-1H-benzimidazol-2-amine, ... (4 entities in total)
• 機能のキーワード: inhibitor, p110, kinase, transferase, atp-binding, p84, p101, transferase-transferase inhibitor complex, transferase/transferase inhibitor
• 由来する生物種: Homo sapiens (human)
• タンパク質・核酸の鎖数: 1
• 化学式量合計: 110419.56

構造登録者

Whittington, D.A.,Tang, J.,Yakowec, P. (登録日: 2011-01-11, 公開日: 2011-03-30, 最終更新日: 2023-09-13)

• 主引用文献: Peterson, E.A.,Andrews, P.S.,Be, X.,Boezio, A.A.,Bush, T.L.,Cheng, A.C.,Coats, J.R.,Colletti, A.E.,Copeland, K.W.,Dupont, M.,Graceffa, R.,Grubinska, B.,Harmange, J.C.,Kim, J.L.,Mullady, E.L.,Olivieri, P.,Schenkel, L.B.,Stanton, M.K.,Teffera, Y.,Whittington, D.A.,Cai, T.,La, D.S.; Discovery of triazine-benzimidazoles as selective inhibitors of mTOR.; Bioorg.Med.Chem.Lett., 21:2064-2070, 2011; PubMed: 21376583; DOI: 10.1016/j.bmcl.2011.02.007

実験手法

X-RAY DIFFRACTION (2.65 Å)