3Q99

Structure of neuronal nitric oxide synthase in the ferric state in complex with N~5~-[(3-(ethylsulfanyl)propanimidoyl]-L-ornithine

3Q99 の概要

• エントリーDOI: 10.2210/pdb3q99/pdb
• 関連するPDBエントリー: 3JT4 3Q9A
• 分子名称: Nitric oxide synthase, brain, PROTOPORPHYRIN IX CONTAINING FE, N~5~-[(3-(ethylsulfanyl)propanimidoyl]-L-ornithine, ... (7 entities in total)
• 機能のキーワード: nitric oxide synthase, heme enzyme, oxidoreductase, inhibitor, oxidoreductase-oxidoreductase inhibitor complex, oxidoreductase/oxidoreductase inhibitor
• 由来する生物種: Rattus norvegicus (Rat)
• 細胞内の位置: Cell membrane, sarcolemma ; Peripheral membrane protein : P29476
• タンパク質・核酸の鎖数: 2
• 化学式量合計: 100018.74

構造登録者

Li, H.,Doukov, T.,Poulos, T.L. (登録日: 2011-01-07, 公開日: 2011-05-18, 最終更新日: 2023-09-13)

• 主引用文献: Doukov, T.,Li, H.,Sharma, A.,Martell, J.D.,Soltis, S.M.,Silverman, R.B.,Poulos, T.L.; Temperature-dependent spin crossover in neuronal nitric oxide synthase bound with the heme-coordinating thioether inhibitors.; J.Am.Chem.Soc., 133:8326-8334, 2011; PubMed: 21534614; DOI: 10.1021/ja201466v

実験手法

X-RAY DIFFRACTION (2.15 Å)