3Q3T

Alkyl Amine Renin Inhibitors: Filling S1 from S3

Summary for 3Q3T

• Entry DOI: 10.2210/pdb3q3t/pdb
• Related: 3GW5 3KM4 3Q4B 3Q5H
• Descriptor: Renin, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, [(1S,3R,4S)-3-amino-4-hydroxycyclopentyl]{(3R)-3-[(1S)-1-(biphenyl-2-yl)-1-hydroxy-5-methoxypentyl]piperidin-1-yl}methanone, ... (6 entities in total)
• Functional Keywords: aspartate protease, hypertension, renin inhibitors, glycoprotein, zymogen, hydrolase-hydrolase inhibitor complex, hydrolase/hydrolase inhibitor
• Biological source: Homo sapiens (human)
• Cellular location: Secreted: P00797
• Total number of polymer chains: 2
• Total formula weight: 76325.09

Authors

Wu, Z.,McKeever, B. (deposition date: 2010-12-22, release date: 2011-08-03, Last modification date: 2023-09-13)

• Primary citation: Yuan, J.,Simpson, R.D.,Zhao, W.,Tice, C.M.,Xu, Z.,Cacatian, S.,Jia, L.,Flaherty, P.T.,Guo, J.,Ishchenko, A.,Wu, Z.,McKeever, B.M.,Scott, B.B.,Bukhtiyarov, Y.,Berbaum, J.,Panemangalore, R.,Bentley, R.,Doe, C.P.,Harrison, R.K.,McGeehan, G.M.,Singh, S.B.,Dillard, L.W.,Baldwin, J.J.,Claremon, D.A.; Biphenyl/diphenyl ether renin inhibitors: Filling the S1 pocket of renin via the S3 pocket.; Bioorg.Med.Chem.Lett., 21:4836-4843, 2011; PubMed: 21741239; DOI: 10.1016/j.bmcl.2011.06.043

Experimental method

X-RAY DIFFRACTION (2.6 Å)