3Q32

Structure of Janus kinase 2 with a pyrrolotriazine inhibitor

3Q32 の概要

• エントリーDOI: 10.2210/pdb3q32/pdb
• 分子名称: Tyrosine-protein kinase JAK2, 2-(2,6-difluoro-4-methoxyphenyl)-1-(4-{4-[(3-methyl-1H-pyrazol-5-yl)amino]pyrrolo[2,1-f][1,2,4]triazin-2-yl}piperazin-1-yl)ethanone (3 entities in total)
• 機能のキーワード: atp-binding, transferase-transferase inhibitor complex, transferase/transferase inhibitor
• 由来する生物種: Homo sapiens (human)
• 細胞内の位置: Endomembrane system; Peripheral membrane protein (By similarity): O60674
• タンパク質・核酸の鎖数: 2
• 化学式量合計: 72356.20

構造登録者

Sack, J.S. (登録日: 2010-12-21, 公開日: 2011-02-16, 最終更新日: 2011-07-13)

主引用文献

Harikrishnan, L.S.,Kamau, M.G.,Wan, H.,Inghrim, J.A.,Zimmermann, K.,Sang, X.,Mastalerz, H.A.,Johnson, W.L.,Zhang, G.,Lombardo, L.J.,Poss, M.A.,Trainor, G.L.,Tokarski, J.S.,Lorenzi, M.V.,You, D.,Gottardis, M.M.,Baldwin, K.F.,Lippy, J.,Nirschl, D.S.,Qiu, R.,Miller, A.V.,Khan, J.,Sack, J.S.,Purandare, A.V.
Pyrrolo[1,2-f]triazines as JAK2 inhibitors: Achieving potency and selectivity for JAK2 over JAK3.
Bioorg.Med.Chem.Lett., 21:1425-1428, 2011

PubMed Abstract: SAR studies of pyrrolo[1,2-f]triazines as JAK2 inhibitors is presented. Achieving JAK2 inhibition selectively over JAK3 is discussed.

PubMed: 21282055
DOI: 10.1016/j.bmcl.2011.01.022

実験手法

X-RAY DIFFRACTION (2.5 Å)