3Q2E

Crystal structure of the second bromodomain of human bromodomain and WD repeat-containing protein 1 isoform A (WDR9)

Summary for 3Q2E

Entry DOI	10.2210/pdb3q2e/pdb
Descriptor	Bromodomain and WD repeat-containing protein 1, ACETATE ION (3 entities in total)
Functional Keywords	structural genomics consortium, sgc, bromodomain, cell cycle progression, signal transduction, apoptosis, gene regulation, down syndrome region-2 on chromosome 21, signaling protein
Biological source	Homo sapiens (human)
Cellular location	Cytoplasm: Q9NSI6
Total number of polymer chains	1
Total formula weight	14506.45
Authors	Filippakopoulos, P.,Felletar, I.,Picaud, S.,Keates, T.,Krojer, T.,Muniz, J.,Gileadi, O.,Von Delft, F.,Arrowsmith, C.H.,Edwards, A.,Weigelt, J.,Bountra, C.,Knapp, S.,Structural Genomics Consortium (SGC) (deposition date: 2010-12-20, release date: 2011-02-16, Last modification date: 2023-11-01)
Primary citation	Filippakopoulos, P.,Picaud, S.,Mangos, M.,Keates, T.,Lambert, J.P.,Barsyte-Lovejoy, D.,Felletar, I.,Volkmer, R.,Muller, S.,Pawson, T.,Gingras, A.C.,Arrowsmith, C.H.,Knapp, S. Histone recognition and large-scale structural analysis of the human bromodomain family. Cell(Cambridge,Mass.), 149:214-231, 2012 Cited by PubMed: 22464331 DOI: 10.1016/j.cell.2012.02.013 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (1.74 Å)

Structure validation