3Q2E

Crystal structure of the second bromodomain of human bromodomain and WD repeat-containing protein 1 isoform A (WDR9)

3Q2E の概要

• エントリーDOI: 10.2210/pdb3q2e/pdb
• 分子名称: Bromodomain and WD repeat-containing protein 1, ACETATE ION (3 entities in total)
• 機能のキーワード: structural genomics consortium, sgc, bromodomain, cell cycle progression, signal transduction, apoptosis, gene regulation, down syndrome region-2 on chromosome 21, signaling protein
• 由来する生物種: Homo sapiens (human)
• 細胞内の位置: Cytoplasm: Q9NSI6
• タンパク質・核酸の鎖数: 1
• 化学式量合計: 14506.45

構造登録者

Filippakopoulos, P.,Felletar, I.,Picaud, S.,Keates, T.,Krojer, T.,Muniz, J.,Gileadi, O.,Von Delft, F.,Arrowsmith, C.H.,Edwards, A.,Weigelt, J.,Bountra, C.,Knapp, S.,Structural Genomics Consortium (SGC) (登録日: 2010-12-20, 公開日: 2011-02-16, 最終更新日: 2023-11-01)

• 主引用文献: Filippakopoulos, P.,Picaud, S.,Mangos, M.,Keates, T.,Lambert, J.P.,Barsyte-Lovejoy, D.,Felletar, I.,Volkmer, R.,Muller, S.,Pawson, T.,Gingras, A.C.,Arrowsmith, C.H.,Knapp, S.; Histone recognition and large-scale structural analysis of the human bromodomain family.; Cell(Cambridge,Mass.), 149:214-231, 2012; PubMed: 22464331; DOI: 10.1016/j.cell.2012.02.013

実験手法

X-RAY DIFFRACTION (1.74 Å)