3Q13

The Structure of the Ca2+-binding, Glycosylated F-spondin Domain of F-spondin, A C2-domain Variant from Extracellular Matrix

Summary for 3Q13

• Entry DOI: 10.2210/pdb3q13/pdb
• Descriptor: Spondin-1, beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, CALCIUM ION, ... (6 entities in total)
• Functional Keywords: f-spondin, fs-domain, membrane targeting, axon guidance, c2-domain derivative, glycosylated, extracellular matrix, cell adhesion
• Biological source: Homo sapiens (human)
• Cellular location: Secreted, extracellular space, extracellular matrix (By similarity): Q9HCB6
• Total number of polymer chains: 1
• Total formula weight: 29903.31

Authors

Tan, K.,Lawler, J. (deposition date: 2010-12-16, release date: 2011-06-29, Last modification date: 2023-09-13)

Primary citation

Tan, K.,Lawler, J.
The structure of the Ca2+-binding, glycosylated F-spondin domain of F-spondin - A C2-domain variant in an extracellular matrix protein.
Bmc Struct.Biol., 11:22-22, 2011

PubMed Abstract: F-spondin is a multi-domain extracellular matrix (ECM) protein and a contact-repellent molecule that directs axon outgrowth and cell migration during development. The reelin_N domain and the F-spondin domain (FS domain) comprise a proteolytic fragment that interacts with the cell membrane and guides the projection of commissural axons to floor plate. The FS domain is found in F-spondins, mindins, M-spondin and amphiF-spondin.

PubMed: 21569239
DOI: 10.1186/1472-6807-11-22

Experimental method

X-RAY DIFFRACTION (1.95 Å)