3Q0T

Crystal structure of human dpp-iv in complex withsa-(+)- methyl2-(3-(aminomethyl)-4-(2,4-dichlorophenyl)-2-methyl- 7-oxo-5h-pyrrolo[3,4-b]pyridin-6(7h)-yl)acetate

Summary for 3Q0T

• Entry DOI: 10.2210/pdb3q0t/pdb
• Related: 3BJM 3NOX 3SWW 3SX4
• Descriptor: Dipeptidyl peptidase 4, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose, ... (5 entities in total)
• Functional Keywords: exopeptidase, alpha/beta hydrolase fold, beta barrel, beta propeller, aminopeptidase, glycoprotein, membrane, serine protease, signal-anchor, transmembrane, hydrolase-hydrolase inhibitor complex, hydrolase/hydrolase inhibitor
• Biological source: Homo sapiens (human)
• Total number of polymer chains: 2
• Total formula weight: 178751.07

Authors

Klei, H.E. (deposition date: 2010-12-16, release date: 2012-02-29, Last modification date: 2023-09-13)

• Primary citation: Wang, W.,Devasthale, P.,Wang, A.,Egan, D.,Morgan, N.,Cap, M.,Fura, A.,Klei, H.E.,Kish, K.,Sun, L.,Levesque, P.,Zahler, R.,Kirby, M.,Hamann, L.G.; Discovery of 7-oxo-pyrrolopyridines as potent and selective inhibitors of dpp4; To be Published,

Experimental method

X-RAY DIFFRACTION (2.401 Å)