3Q0T

Crystal structure of human dpp-iv in complex withsa-(+)- methyl2-(3-(aminomethyl)-4-(2,4-dichlorophenyl)-2-methyl- 7-oxo-5h-pyrrolo[3,4-b]pyridin-6(7h)-yl)acetate

3Q0T の概要

• エントリーDOI: 10.2210/pdb3q0t/pdb
• 関連するPDBエントリー: 3BJM 3NOX 3SWW 3SX4
• 分子名称: Dipeptidyl peptidase 4, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose, ... (5 entities in total)
• 機能のキーワード: exopeptidase, alpha/beta hydrolase fold, beta barrel, beta propeller, aminopeptidase, glycoprotein, membrane, serine protease, signal-anchor, transmembrane, hydrolase-hydrolase inhibitor complex, hydrolase/hydrolase inhibitor
• 由来する生物種: Homo sapiens (human)
• タンパク質・核酸の鎖数: 2
• 化学式量合計: 178751.07

構造登録者

Klei, H.E. (登録日: 2010-12-16, 公開日: 2012-02-29, 最終更新日: 2023-09-13)

• 主引用文献: Wang, W.,Devasthale, P.,Wang, A.,Egan, D.,Morgan, N.,Cap, M.,Fura, A.,Klei, H.E.,Kish, K.,Sun, L.,Levesque, P.,Zahler, R.,Kirby, M.,Hamann, L.G.; Discovery of 7-oxo-pyrrolopyridines as potent and selective inhibitors of dpp4; To be Published,

実験手法

X-RAY DIFFRACTION (2.401 Å)