3PYK

Human Carbonic Anhydrase II as Host for Pianostool Complexes Bearing a Sulfonamide Anchor

3PYK の概要

• エントリーDOI: 10.2210/pdb3pyk/pdb
• 分子名称: Carbonic anhydrase 2, ZINC ION, chloro{N-[di(pyridin-2-yl-kappaN)methyl]-4-sulfamoylbenzamide}[(1,2,3,4,5,6-eta)-(1R,2R,3R,4S,5S,6S)-1,2,3,4,5,6-hexamethylcyclohexane-1,2,3,4,5,6-hexayl]ruthenium(2+), ... (6 entities in total)
• 機能のキーワード: 10 stranded, twisted beta-sheets, carbonate dehydratase activity, protein binding, zinc ion binding, lyase activity, metal ion binding, co2, bicarbonate, sulfonamides, metal ions, lyase-lyase inhibitor complex, lyase/lyase inhibitor
• 由来する生物種: Homo sapiens (human)
• 細胞内の位置: Cytoplasm: P00918
• タンパク質・核酸の鎖数: 1
• 化学式量合計: 30317.36

構造登録者

Heinisch, T.,Schirmer, T. (登録日: 2010-12-13, 公開日: 2011-07-13, 最終更新日: 2023-09-13)

• 主引用文献: Monnard, F.W.,Heinisch, T.,Nogueira, E.S.,Schirmer, T.,Ward, T.R.; Human Carbonic Anhydrase II as a host for piano-stool complexes bearing a sulfonamide anchor.; Chem.Commun.(Camb.), 47:8238-8240, 2011; PubMed: 21706094; DOI: 10.1039/c1cc10345h

実験手法

X-RAY DIFFRACTION (1.3 Å)