3PUR

CEKDM7A from C.Elegans, complex with D-2-HG

Summary for 3PUR

• Entry DOI: 10.2210/pdb3pur/pdb
• Related: 3PUQ
• Descriptor: Lysine-specific demethylase 7 homolog, FE (II) ION, ZINC ION, ... (5 entities in total)
• Functional Keywords: demethylase, oxidoreductase-oxidoreductase inhibitor complex, oxidoreductase/oxidoreductase inhibitor
• Biological source: Caenorhabditis elegans (nematode)
• Cellular location: Nucleus: Q9GYI0
• Total number of polymer chains: 2
• Total formula weight: 124560.55

Authors

Yang, Y.,Wang, P.,Xu, W.,Xu, Y. (deposition date: 2010-12-06, release date: 2011-01-26, Last modification date: 2024-03-20)

• Primary citation: Xu, W.,Yang, H.,Liu, Y.,Yang, Y.,Wang, P.,Kim, S.-H.,Ito, S.,Yang, C.,Wang, P.,Xiao, M.-T.,Liu, L.-X.,Jiang, W.-Q.,Liu, J.,Zhang, J.-Y.,Wang, B.,Frye, S.,Zhang, Y.,Xu, Y.-H.,Lei, Q.-Y.,Guan, K.-L.,Zhao, S.-M.,Xiong, Y.; Oncometabolite 2-hydroxyglutarate is a competitive inhibitor of alpha-ketoglutarate-dependent dioxygenases; Cancer Cell, 19:17-30, 2011; PubMed: 21251613; DOI: 10.1016/j.ccr.2010.12.014

Experimental method

X-RAY DIFFRACTION (2.1 Å)