3PSD

Non-oxime pyrazole based inhibitors of B-Raf kinase

3PSD の概要

• エントリーDOI: 10.2210/pdb3psd/pdb
• 関連するPDBエントリー: 3D4Q 3PSB
• 分子名称: B-RAF PROTO-ONCOGENE SERINE/THREONINE-PROTEIN KINASE, 6-[1-(piperidin-4-yl)-3-(pyridin-4-yl)-1H-pyrazol-4-yl]indeno[1,2-c]pyrazole (2 entities in total)
• 機能のキーワード: kinase, atp-binding, cardiomyopathy, disease mutation, metal-binding, nucleotide-binding, phorbol-ester binding, phosphoprotein, proto-oncogene, serine/threonine-protein kinase, zinc-finger, transferase-transferase inhibitor complex, transferase/transferase inhibitor
• 由来する生物種: Homo sapiens (human)
• 細胞内の位置: Nucleus : P15056
• タンパク質・核酸の鎖数: 2
• 化学式量合計: 71196.16

構造登録者

Morales, T.,Vigers, G.P.A.,Brandhuber, B.J. (登録日: 2010-12-01, 公開日: 2011-05-18, 最終更新日: 2023-09-06)

• 主引用文献: Newhouse, B.J.,Hansen, J.D.,Grina, J.,Welch, M.,Topalov, G.,Littman, N.,Callejo, M.,Martinson, M.,Galbraith, S.,Laird, E.R.,Brandhuber, B.J.,Vigers, G.,Morales, T.,Woessner, R.,Randolph, N.,Lyssikatos, J.,Olivero, A.; Non-oxime pyrazole based inhibitors of B-Raf kinase.; Bioorg.Med.Chem.Lett., 21:3488-3492, 2011; PubMed: 21536432; DOI: 10.1016/j.bmcl.2010.12.038

実験手法

X-RAY DIFFRACTION (3.6 Å)