3PQZ

Grb7 SH2 with peptide

Summary for 3PQZ

• Entry DOI: 10.2210/pdb3pqz/pdb
• Descriptor: Growth factor receptor-bound protein 7, cyclic peptide (3 entities in total)
• Functional Keywords: sh2, binds phosphotyrosine, tyrosine kinases, cytoplasmic, protein binding
• Biological source: Homo sapiens (human); More
• Total number of polymer chains: 6
• Total formula weight: 56670.86

Authors

Wilce, J.A. (deposition date: 2010-11-29, release date: 2011-07-20, Last modification date: 2011-09-21)

• Primary citation: Ambaye, N.D.,Pero, S.C.,Gunzburg, M.J.,Yap, M.,Clayton, D.J.,Del Borgo, M.P.,Perlmutter, P.,Aguilar, M.I.,Shukla, G.S.,Peletskaya, E.,Cookson, M.M.,Krag, D.N.,Wilce, M.C.,Wilce, J.A.; Structural basis of binding by cyclic nonphosphorylated Peptide antagonists of grb7 implicated in breast cancer progression; J.Mol.Biol., 412:397-411, 2011; PubMed: 21802427; DOI: 10.1016/j.jmb.2011.07.030

Experimental method

X-RAY DIFFRACTION (2.413 Å)