3PO7

Human monoamine oxidase B in complex with zonisamide

3PO7 の概要

• エントリーDOI: 10.2210/pdb3po7/pdb
• 分子名称: Amine oxidase [flavin-containing] B, FLAVIN-ADENINE DINUCLEOTIDE, 1-(1,2-benzoxazol-3-yl)methanesulfonamide, ... (4 entities in total)
• 機能のキーワード: flavin-binding amine oxidase, neurotransmitter metabolism, fad, mitochondrial outer membrane, antiparkinson drug, oxidoreductase, oxidoreductase-oxidoreductase inhibitor complex, oxidoreductase/oxidoreductase inhibitor
• 由来する生物種: Homo sapiens (human)
• 細胞内の位置: Mitochondrion outer membrane; Single-pass type IV membrane protein; Cytoplasmic side: P27338
• タンパク質・核酸の鎖数: 2
• 化学式量合計: 119671.01

構造登録者

Binda, C.,Aldeco, M.,Mattevi, A.,Edmondson, D.E. (登録日: 2010-11-22, 公開日: 2011-01-12, 最終更新日: 2024-11-06)

主引用文献

Binda, C.,Aldeco, M.,Mattevi, A.,Edmondson, D.E.
Interactions of monoamine oxidases with the antiepileptic drug zonisamide: specificity of inhibition and structure of the human monoamine oxidase B complex
J.Med.Chem., 54:909-912, 2011

PubMed Abstract: The binding of zonisamide to purified, recombinant monoamine oxidases (MAOs) has been investigated. It is a competitive inhibitor of human MAO B (K(i) = 3.1 ± 0.3 μM), of rat MAO B (K(i) = 2.9 ± 0.5 μM), and of zebrafish MAO (K(i) = 30.8 ± 5.3 μM). No inhibition is observed with purified human or rat MAO A. The 1.8 Å structure of the MAO B complex demonstrates that it binds within the substrate cavity.

PubMed: 21175212
DOI: 10.1021/jm101359c

実験手法

X-RAY DIFFRACTION (1.8 Å)